Structure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of Neuroprotection
Identifieur interne : 000C64 ( Main/Exploration ); précédent : 000C63; suivant : 000C65Structure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of Neuroprotection
Auteurs : Jean-François Trempe [Canada] ; Edward A. Fon [Canada]Source :
- Frontiers in Neurology [ 1664-2295 ] ; 2013.
Abstract
Autosomal recessive forms of Parkinson’s disease are caused by mutations in three genes:
Url:
DOI: 10.3389/fneur.2013.00038
PubMed: 23626584
PubMed Central: 3630392
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Structure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of Neuroprotection</title><author><name sortKey="Trempe, Jean Francois" sort="Trempe, Jean Francois" uniqKey="Trempe J" first="Jean-François" last="Trempe">Jean-François Trempe</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>McGill Parkinson Program, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University</institution><country>Montreal, QC, Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Fon, Edward A" sort="Fon, Edward A" uniqKey="Fon E" first="Edward A." last="Fon">Edward A. Fon</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>McGill Parkinson Program, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University</institution><country>Montreal, QC, Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea></wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23626584</idno><idno type="pmc">3630392</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630392</idno><idno type="RBID">PMC:3630392</idno><idno type="doi">10.3389/fneur.2013.00038</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000C24</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000C24</idno><idno type="wicri:Area/Pmc/Curation">000C24</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000C24</idno><idno type="wicri:Area/Pmc/Checkpoint">000575</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000575</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000928</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000928</idno><idno type="wicri:Area/PubMed/Curation">000928</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000928</idno><idno type="wicri:Area/PubMed/Checkpoint">000928</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000928</idno><idno type="wicri:Area/Ncbi/Merge">001441</idno><idno type="wicri:Area/Ncbi/Curation">001441</idno><idno type="wicri:Area/Ncbi/Checkpoint">001441</idno><idno type="wicri:Area/Main/Merge">000C70</idno><idno type="wicri:Area/Main/Curation">000C64</idno><idno type="wicri:Area/Main/Exploration">000C64</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Structure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of Neuroprotection</title><author><name sortKey="Trempe, Jean Francois" sort="Trempe, Jean Francois" uniqKey="Trempe J" first="Jean-François" last="Trempe">Jean-François Trempe</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>McGill Parkinson Program, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University</institution><country>Montreal, QC, Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Fon, Edward A" sort="Fon, Edward A" uniqKey="Fon E" first="Edward A." last="Fon">Edward A. Fon</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>McGill Parkinson Program, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University</institution><country>Montreal, QC, Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea></wicri:regionArea></affiliation></author></analytic><series><title level="j">Frontiers in Neurology</title><idno type="eISSN">1664-2295</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Autosomal recessive forms of Parkinson’s disease are caused by mutations in three genes: <italic>Parkin</italic>, <italic>PINK1</italic>, and <italic>DJ-1</italic>. These genes encode for proteins with distinct enzymatic activities that may work together to confer neuroprotection. Parkin is an E3 ubiquitin ligase that has been shown to ubiquitinate substrates and to trigger proteasome-dependent degradation or autophagy, two crucial homeostatic processes in neurons. PINK1 is a mitochondrial protein kinase whose activity is required for Parkin-dependent mitophagy, a process that has been linked to neurodegeneration. Finally, DJ-1 is a protein homologous to a broad class of bacterial enzymes that may function as a sensor and modulator of reactive oxygen species, which have been implicated in neurodegenerative diseases. Here, we review the literature on the structure and biochemical functions of these three proteins.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Beasley, S A" uniqKey="Beasley S">S. A. Beasley</name></author><author><name sortKey="Hristova, V A" uniqKey="Hristova V">V. A. Hristova</name></author><author><name sortKey="Shaw, G S" uniqKey="Shaw G">G. S. 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Zhou</name></author><author><name sortKey="Huang, Y" uniqKey="Huang Y">Y. Huang</name></author><author><name sortKey="Shao, Y" uniqKey="Shao Y">Y. Shao</name></author><author><name sortKey="May, J" uniqKey="May J">J. May</name></author><author><name sortKey="Prou, D" uniqKey="Prou D">D. Prou</name></author><author><name sortKey="Perier, C" uniqKey="Perier C">C. Perier</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Trempe, Jean Francois" sort="Trempe, Jean Francois" uniqKey="Trempe J" first="Jean-François" last="Trempe">Jean-François Trempe</name></noRegion><name sortKey="Fon, Edward A" sort="Fon, Edward A" uniqKey="Fon E" first="Edward A." last="Fon">Edward A. Fon</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:3630392
|texte= Structure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of Neuroprotection
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:23626584" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonCanadaV1
| This area was generated with Dilib version V0.6.29. |  |